The type III secretion system (T3SS) is a specialized nanomachine that enables bacteria to secrete proteins in a specific order and directly deliver a specific set of them, collectively known as effectors, into eukaryotic organisms. The core structure of the T3SS is a syringe‐like apparatus composed of multiple building blocks, including both membrane‐associated and soluble proteins. The cytosolic components organize together in a chamber‐like structure known as the sorting platform (SP), responsible for recruiting, sorting, and initiating the substrates destined to (...) engage this secretion pathway. In this article, we provide an overview of recent findings on the SP's structure and function, with a particular focus on its assembly pathway. Furthermore, we discuss the molecular mechanisms behind the recruitment and hierarchical sorting of substrates by this cytosolic complex. Overall, the T3SS is a highly specialized and complex system that requires precise coordination to function properly. A deeper understanding of how the SP orchestrates T3S could enhance our comprehension of this complex nanomachine, which is central to the host‐pathogen interface, and could aid in the development of novel strategies to fight bacterial infections. (shrink)

The question of how psychiatric classifications are made up and to what they refer has attracted the attention of philosophers in recent years. In this paper, I review the claims of authors who discuss psychiatric classification in terms referring both to the philosophical tradition of natural kinds and to the sociological tradition of social constructionism — especially those of Ian Hacking and his critics. I examine both the ontological and the social aspects of what it means for something to be (...) a mental disorder, and how the ontological status of these disorders hinges on social causation. Finally, I conclude by suggesting a way in which the biological and the social may be reconciled in an integrative model of variation in psychiatric disorder. (shrink)

This article is about the novel role of the Unión de Naciones Suramericanas (South American Nations Union) - UNASUR as a peacekeeper in the SouthAmerican region. It begins with an overview of UNASUR, its history, legal framework, and its mandate related to peacekeeping activities. Then, the efforts for regional integration and peacekeeping are addressed, with an explanation of the different frameworks backing those intents and the new peacemaking body known as UNASUR. Examples of political conflict are outlined, namely those in (...) Bolivia and Venezuela, and the ways in which the novel intervention of UNASUR deescalated the violence. After providing a brief description of South American history, its recent conflicts, and a review of some applicable conflict causation theories, the article concludes with a theoretical explanation of the role of UNASUR and its intervention for building peace in the region. This leads to questions and suggestions about how the work of UNASUR can be protected and enhanced to benefit the creation and maintenance of harmonious relationships within South American states. (shrink)

Clinical delusions are widely characterized as being pathological beliefs in both the clinical literature and in common sense. Recently, a philosophical debate has emerged between defenders of the commonsense position (doxasticists) and their opponents, who have the burden of pointing toward alternative characterizations (anti-doxasticists). In this chapter, I argue that both doxasticism and anti- doxasticism fail to characterize the functional role of delusions while at the same time being unable to play a role in the explanation of these phenomena. I (...) also argue that though a more nuanced view of belief in which mental states are more or less belief-like instills a healthy skepticism towards the precision of folk-psychological concepts, such a stance fails to be of use in building a theory of delusion that will be able to bridge different levels of explanation, such as the phenomenology and neurobiology of delusion. Thus, I advocate moving past the question ‘Are delusions beliefs?’ and their description as propositional attitudes toward the description of the processes that generate delusion, with a view toward explaining, rather than explaining away, the personal-level aspects of the phenomenon that have been made inscrutable by investing in doxastic terminology. (shrink)

O texto apresenta a apropriação feita pela extrema-direita brasileira ao redor da obra de George Orweel, em especial, de '1984' e 'Animal Farm'. Argumentamos que a adjudicação 'conservadora' é inadequada para tal apropriação. Os intelectuais e editoriais implicados na circulação atual de Orwell nas redes bolsonaristas permite ver como clássicos do pensamento conservador ocidental são aqui canonizados em chave, mais que conservadora, reacionária. Além disso, o duelo de distopias empunhados pelos ideólogos da extrema-direita dá também acesso a uma indústria cultural, (...) na qual um sem-fim de produtos culturais são vendidos para forjar e cativar uma plateia potencial reacionária. (shrink)

Clinical delusions are commonly thought of and characterized as beliefs, both by psychiatrists and by the general population. That fact is encoded in the definition of delusion in the Glossary of Technical Terms of the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders :A false belief based on incorrect inference about external reality that is firmly held despite what almost everyone else believes and despite what constitutes incontrovertible and obvious proof or evidence to the contrary.Although almost (...) every aspect of this definition is debatable, describing delusion as a type of aberrant belief has engendered a specialized discussion in itself, engaging philosophers... (shrink)

I assess Tamar Gendler's (2007) account of self-deception according to which its characteristic state is not belief, but imaginative pretense. After giving an overview of the literature and presenting the conceptual puzzles engendered by the notion of self-deception, I introduce Gendler's account, which emerges as a rival to practically all extant accounts of self-deception. I object to it by first arguing that her argument for abandoning belief as the characteristic state of self-deception conflates the state of belief and the process (...) of belief-formation when interpreting David Velleman's (2000) thesis that belief is an essentially truth-directed attitude. I then call attention to the fact that Velleman's argument for the identity of motivational role between belief and imagining, on which Gendler's argument for self-deception as pretense depends, conflates two senses of 'motivational role'-a stronger but implausible sense and a weaker but explanatorily irrelevant sense. Finally, I introduce Neil Van Leeuwen's (2009) argument to the effect that belief is the practical ground of all non-belief cognitive attitudes in circumstances wherein the latter prompt action. I apply this framework to Gendler's account to ultimately show that imaginative pretense fails to explain the existence of voluntary actions which result from self-deception. (shrink)

Para Robert Nozick, é preciso entender se o Estado é necessário e o modo como ele pode ser compreendido sem ofender direitos. O presente trabalho tem por objetivo explorar conceitos elementares da teoria de Robert Nozick para a conformação de uma teoria política razoável. Inicialmente, foi apresentado um panorama da concepção libertária desenvolvida por Nozick, baseado na primeira parte da obra Anarquia, Estado e Utopia, tendo em vista que é um autor de bases teóricas distintas e pouco estudado pela academia. (...) Posteriormente, foram analisados alguns aspectos de sua ideia de sociedade política e de seus integrantes, confrontando com conceitos teóricos do pensador contemporâneo John Rawls. Por fim, algumas características de tese de Nozick foram examinados para entender se seria uma doutrina abrangente e como poderia ser caracterizada como racional e razoável frente a pluralidade de concepções da boa vida. (shrink)

Self-deception poses serious difficulties for belief attribution because the behavior of the self-deceived is deeply conflicted: some of it supports the attribution of a certain belief, while some of it supports the contrary attribution. Theorists have resorted either to attributing both beliefs to the self-deceived, or to postulating an unconscious belief coupled with another kind of cognitive attitude. On the other hand, deflationary accounts of self- deception have attempted a more parsimonious solution: attributing only one, false belief to the subject. (...) My aim in this paper is to critically examine this strategy and, subsequently, to suggest that its failure gives support to the neglected view that the self-deceived are not accurately describable as believing either of the relevant propositions. (shrink)

The article intends to discuss processes of political subjectivation of children and young people based on excerpts from a research carried out within the scope of a master's degree in education, presenting a cartography of the political participation of children and young people living in vulnerable territories of the municipality of São Vicente, on the south coast from São Paulo, members of collectives and educational actions of the Instituto Camará Calunga. The concepts of mobilization and subjectivation are presented as important (...) elements of politicization processes, portraying the way in which children and young people engage politically in different ways, coordinated or supported by adults, representing themselves or supporting adults in their demands, opposing the notion that children do not act politically or that the ideal way for children and young people to participate would be to produce consensus and there would be no room for contestation. The research took place in the midst of the COVID-19 pandemic, essentially in a virtual way, but it traces a continuity with the Institute's participation practices in the pre-pandemic period. The research made use of the cartographic method, in a virtual and face-to-face way, in the context of live work, of daily living with children, young people and educators from Camará, through semi-structured interviews and field diaries. (shrink)

The doxastic status of delusion is inconclusive. The arguments presented for and against it are not strong enough to clinch the issue and convince everyone of a single, general characterization. But that does not mean that we have not gained any clarity from discussing it. In the few decades since the issue became contentious, philosophers have made great strides, not only in accounting for the nature of delusion as a cognitive attitude, but also in developing theories of what kind of (...) cognitive attitude best exemplifies the functional role delusions play in one’s cognitive economy.As is often the case within philosophical debates, it takes a long time and a major collective effort for us to start to get clear on... (shrink)

Although delusion is one of the central concepts of psychopathology, it stills eludes precise conceptualization. In this paper, I present certain basic issues concerning the classification and definition of delusion, as well as its ontological status. By examining these issues, I aim to shed light on the ambiguity of the clinical term ‘delusion’ and its extension, as well as provide clues as to why philosophers are increasingly joining the ranks of psychiatrists, psychologists, and neuroscientists in the effort to come to (...) a comprehensive understanding of delusion. (shrink)

In this paper I discuss the scientific respectability of delusion as a psychiatric category. First, I present the essentialist objection to the natural kindhood of psychiatric categories, as well as non-essentialism about natural kinds as a response to that objection. Second, I present a nuanced classification of kinds of kinds. Third, drawing on the claim that the attribution of delusion relies on a folk psychological underpinning, I present the mind-dependence objection to the natural kind status of delusion. Finally, I argue (...) that even if delusion as a generic kind stands little chance of being vindicated as a non-essentialist natural kind, we stand to gain from a natural kind methodology regarding subtypes of delusion for which there is evidence of genuine causal signatures and mechanisms. (shrink)

L'histoire de la réception littéraire de l'Utopie de Thomas More au Portugal a été une histoire d'omissions, de censures et de traductions différées qui met en évidence un défaut dans le système culturel portugais. En effet, il est quelque peu ironique qu'une œuvre aussi représentative de la littérature et de la pensée occidentale, historiquement associée à l'ouverture des horizons géographiques du monde, et qui attribue au personnage d'un marin lusitanien, Raphaël Hythlodée, la découverte d'un lieu idéal, n'a été traduite en (...) portugais que dans la seconde moitié du vingtième siècle. Cependant, la première décennie du vingt-et-unième siècle semble annoncer une fortune littéraire plus favorable à l'Utopie de More dans la langue portugaise: non seulement une édition du chef d'œuvre de More a finalement été traduite du latin, mais aussi deux romans ont été publiés en 2004, A lenda de Martim Regos, de Pedro Canais, et Rafael, de Manuel Alegre. Dans le cadre de leurs propres déroulements narratifs, les deux œuvres réaccentuent les traits complexes du personnage du marin portugais et découvreur de l'île idéale. La même réinvention du personnage de Raphaël avait déjà été tentée, en 1998, par José V. de Pina Martins dans son long récit dialogique Utopia III. Dans cet essai, je me concentrerai à la fois sur les sources documentaires liées à la culture portugaise qui sont à la base de l'Utopie de More et sur certains aspects pertinents de la réception du personnage de Raphaël Hythlodée dans les romans susmentionnés. (shrink)

(2000). The eternal present of Utopianism. Critical Review of International Social and Political Philosophy: Vol. 3, The Philosophy of Utopia, pp. 44-55.

The traditional conception of self-deception takes it for an intrapersonal form of interpersonal deception. However, since the same subject is at the same time deceiver and deceived, this means attributing the agent a pair of contradictory beliefs. In the course of defending a deflationary conception of self-deception, Mele [1997] has challenged traditionalists to present convincing evidence that there are cases of self-deception in which what he calls the dual belief-requirement is satisfied. Levy [2009] has responded to this challenge affirming that (...) there is at least one real cases of self-deception that meets this requirement, namely, that of anosognosia. In this family of conditions, the patient apparently believes that there is nothing wrong with her while, at the same time, providing behavioral cues that indicate that the patient is somehow aware of his disease. If Levy is right, then traditionalism about self-deception could be vindicated, after having been widely abandoned due to its need to postulate exotic mental processes in order to make sense of the attribution of contradictory beliefs. In this paper, I assess whether Levy’s response to Mele’s challenge is successful by analyzing his interpretation of the empirical evidence to which he appeals. Finally, I attack the cogency of the underlying commitments about the nature of folk psychology to which one is required to defer in order to draw from conflicting evidence the attribution of contradictory beliefs. (shrink)

Clinical delusions have traditionally been characterized as beliefs in psychiatry. However, philosophers have recently engaged with the empirical literature and produced a number of objections to the so-called doxastic status of delusion, stemming mainly from the mismatch between the functional role of delusions and that expected of beliefs. In response to this, an appeal to dispositionalism about the nature of belief has been proposed to vindicate the doxastic status of delusion. In this paper, I first present the objections to attributing (...) beliefs to delusional patients and the application of dispositionalism in the attempt to vindicate doxasticism. I then assess this application and some responses to the objections to the doxastic characterization. Finally, I offer some conclusions about the limits of folk-psychological concepts in the characterization and explanation of complex psychological phenomena such as delusions. (shrink)

In this paper, we present an abductive argument for the existence of God from the experience of awe at natural beauty. If God’s creative work is a viable explanation for why we experience awe at natural beauty, and there is no satisfactory naturalistic explanation for the origins of such experiences, then we have defeasible evidence that God exists. To evaluate the argument's tenability, we assess the merits of the two main naturalistic frameworks that can be marshaled to answer the question (...) of why human beings experience awe at natural beauty, Wilson's biophilia hypothesis, and Keltner and Haidt's prototype approach to awe. We show shortcomings of both accounts in explaining the relevant experiences and argue that the reliance of these accounts on an adaptationist reading of our aesthetic appreciation of nature entails a commitment to questionable hidden premises: that affordances themselves can figure in the subject's perceptual experience, and that experiences of awe have adaptive value. We maintain that the argument's “empirical” premise is tenable and conclude with directions for future research regarding the argument's “theological” premise. (shrink)

Análise da commedia dell’arte a partir de uma perspectiva histórico-crítica, enfatizando-se as várias maneiras de sua apropriação no século XX.Partindo de elementos da commedia dell’arte, serão ressaltados os temas da migração do teatro de praça para o teatro fechado e a ampliação do modelo da commedia dell’arte para outras formas artísticas do século XX, como o cinema mudo, o circo e o carnaval.

My aim in this paper is to consider the question ‘Why is belief in God not a delusion?’. In the first half of the paper, I distinguish two kinds of religious belief: institutional and personal religious belief. I then review how cognitive science accounts for cultural processes in the acquisition and transmission of institutional religious beliefs. In the second half of the paper, I present the clinical definition of delusion and underline the fact that it exempts cultural beliefs from clinical (...) diagnosis. Finally, I review cognitive models of the intuitive attribution of mental disorders and how they support cultural exemption. Through the comparison of the models of cultural acquisition of religious beliefs and of cultural exemption in the attribution of delusion I intend to make it clear that we can provide an answer to our motivating question: even though some institutional religious beliefs may seem as strange as the most florid delusions, humans can readily recognize that they are not the product of mental dysfunction due to the fact that their acquisition and transmission is embedded within a cultural context. (shrink)

In this manuscript we describe Proteogenomics Viewer, a web‐based tool that collects MS peptide identification, indexes to genomic sequence and structure, assigns exon usage, reports the identified protein isoforms with genomic alignments and, most importantly, allows the inspection of MS2 information for proper peptide identification. It also provides all performed indexing to facilitate global analysis of the data. The relevance of such tool is that there has been an increase in the number of proteogenomic efforts to improve the annotation of (...) both genomics and proteomics data, culminating with the release of the two human proteome drafts. It is now clear that mass spectrometry‐based peptide identification of uncharacterized sequences, such as those resulting from unpredicted exon joints or non‐coding regions, is still prone to a higher than expected false discovery rate. Therefore, proper visualization of the raw data and the corresponding genome alignments are fundamental for further data validation and interpretation. (shrink)

Este artigo traça um paralelo entre os eventos da Odisseia e a exploração dos jogos de azar. Para tanto, utilizando-se livremente de várias abordagens filosóficas, é defendido que o ser humano é naturalmente um jogador, com uma liberdade que é restrita a partir do surgimento do Estado. Este, tendo seus desdobramentos representados por Calipso, Cila e Caríbdis, terá que harmonizar essa natureza com seu poder soberano, regulamentando a exploração dos jogos de azar.

Th e a r ticl e e xplore s h o w globalizatio n i s assumin g a pr o g ress i v e emptyin g o f the s o v ereignt y o f natio n state s i n economic , political , institutional , social , cultura l an d l e gal aspects . Th e traditiona l l e ga l institution s ar e increasing ly g i vin g ris e (...) t o n ew non-stat e re- gulato r y source s (supranational , pr iv ate , technica l an d communitarian) . Th e resul t o f this po l ycentri c r e gulato r y compl e x i s th e co e xistenc e o f a d i v ersit y o f no r mat i v e order s and jurisdiction s i n v olvin g th e e xhaustio n o f th e l e ga l paradig m aroun d w hic h th e Stat e has st r ucture d it s institutions. (shrink)

O que se buscará com o seguinte artigo é recriar, e analisar, o trajeto filosófico que tem sua origem no conceito kantiano de Aufklärung, e cuja evolução nos levará até o conceito foucaultiano de “ontologia crítica”. Em 1784, Kant diria num artigo do jornal alemão Berlinische Monatsschrift que a Aufklärung seria uma saída da minoridade do homem, e por minoridade podemos entender o fato do homem não ser capaz de fazer uso do seu próprio entendimento, ficando assim dependente da razão (...) de tutores. A partir disto, Foucault, em 1984, diria que a originalidade desta resposta de Kant está exatamente em não propor um método ou uma doutrina, mas antes, em incitar uma ação: propriamente a ação de saída [Ausgang]. Assim, Foucault nos apresentaria sua “ontologia crítica”; que diferentemente da ontologia tradicional que busca capturar os acontecimentos numa doutrina, o papel da ontologia foucaultiana seria exatamente o de tornar o sujeito incapturável por qualquer doutrina que apreende os acontecimentos num SER exclusivo. O que Foucault faria, desta forma, seria levar o conceito de Kant mais além, propondo mesmo um trabalho infinito, não apenas mais para sair, mas para igualmente permanecer fora do estado de minoridade. (shrink)

Raimundo Lulio contempla el derecho, como toda otra realidad del mundo creado, desde una filosofía de fe, de fe cristiana, o sea, desde una forma de razonar en servicio de la teología, en cuanto que de ese razonamiento recaba los argumentos demostrativos de la fe cristiana. El derecho es una ciencia confusa, necesaria a los hombres por la ausencia de caridad. La actividad jurídica, que Raimundo Lulio demuestra conocer bien, le parece prolija y compleja en demasía: por ello, a través (...) de su "Arte", propone una metodología, un sistema simplificado y mecánico para aplicar el derecho y hacer justicia, fundamentado en principios teológicos y de derecho natural. Raimundo Lulio juega, en fin, a la utopía. (shrink)

SÍNTESE - El decreto de Graciano sefiala el momento decisivo de la juridización de la Iglesia. AI tiempo, surgen algunas voces de teólogos em contra de dicha juridización. Son teólogos que entienden que la vinculación dei cristiano a unos comportamientos determinados no puede dimanar de una normativa humana, sea civil o eclesiástica, sino sólo de la voluntad de Dios manifestada en el derecho natural y en la Biblia, según viene interpretada por los Padres de la Iglesia y por las determinaciones (...) de los concillos y de los papas. En este sentido se expresan concretamente dos teólogos hispanos de los siglos XII y XIII, Martino de León y Antonio de Lisboa. Posteriormente, segunda mitad dei siglo XIII y principios dei XN, Raimundo Lulio contacta com esa tendencia, ai elaborar una teoria en la que e! derecho queda reducido a filosofia moral. Ya em pleno siglo X:V, un autor hispano anónimo da testimonio de que algunos teólogos siguen manteniendo la tesis de una Iglesia governada por la sola teología, sin necesidad del derecho. Los autores mencionados no representan uma tradición hispana. Martino y Antonio conectan en su formación teológíca con una corriente espiritualista que procede de Francia, y Raimundo es autónomo en su teoria. (shrink)

La principal preocupación ética en una sociedad tecnocientífica es la responsabilidad con la que se manipula el ambiente y las consecuencias que este desate ante un trato desmesurado o despreocupado. Hans Jonas apuesta a favor de la libertad de nuestras acciones como principal eje con el que nos relacionamos responsablemente con el mundo. En el siguiente artículo discutiremos sobre el poder y el deber humano bajo la lupa de la responsabilidad, y en definitiva, sobre la revalorización ontológica de la Naturaleza (...) y la preservación del ser en este nuevo horizonte ético que fundamenta Jonas como el nuevo corazón de la ética del futuro. Algunas de las preguntas clave serán: ¿qué ocurre con el pronóstico de las consecuencias de una acción para la humanidad y para con la Naturaleza? ¿qué es y de qué forma hablamos de la responsabilidad? ¿cuántos errores y pruebas podemos permitirnos en una cadena de eventos tecnológicos donde está en juego el futuro de la humanidad y su dignidad como condición imprescindible? (shrink)

El panorama educativo actual requiere de la implementación de nuevas metodologías docentes en el Espacio Europeo de Educación Superior. El objetivo de este trabajo es presentar un estudio piloto orientado a impartir docencia al aire libre como forma de recrear el trabajo real que puede desarrollar nuestro alumnado en su futuro profesional. De este modo, pretendíamos conseguir un aprendizaje significativo en tanto que existe una interacción real con los objetos de aprendizaje. El resultado se concretó en la valoración positiva por (...) parte del alumnado al sentirse conectados con su inminente realidad laboral y la adquisición de competencias interpersonales como la cooperación y el compañerismo. (shrink)

Se realizó un estudio cuali-cuantitativo en la Comunidad Rural "El León" de la provincia de Camagüey. Se utilizó el método etnográfico y la evaluación del Análisis de la Situación de Salud en el periodo 2007-2015 con el objetivo de describir las características socio históricas y de salud de esta población, conjuntamente con profesionales de enfermería comunitaria. Se crearon instrumentos validados por expertos. Se aplicaron grupos focales, observación participante, entrevistas en profundidad a informantes clave, socioculturales, estructuradas abiertas y la cerrada para (...) combinarla con los resultados del Análisis de la Situación de Salud en el proceder cuantitativo. Se triangularon sus resultados. Se evidenció: falta de sentido de pertenencia de los pobladores, indisciplinas sociales que perjudican la comunidad y su salud, deterioro de las relaciones interpersonales, sistema eco cultural deficiente, y se identificó la necesidad de emprender otras acciones comunitarias que provoquen el cambio y modifiquen el cuadro de salud comunitaria. The quantitative and qualitative in the Community Rural accomplished a study itself "The Lion" of Camagüey's province. The 2007-2015 for the sake of describing the characteristics utilized the ethnographic method and the evaluation of Health's Analysis of the Situation in the period itself member historic and of health of this population together with nursing professionals, communal. They created instruments validated by experts. They applied focal groups, participating observation, you interview key, socio cultural to informants in depth, structured open and the closed to combine it with the results of Health's Analysis of the Situation in the quantitative action. They triangulated his results. It became evident: The inhabitants's pointlessness of possession, social indiscipline that the community and his health, deterioration of personal relations, system harm cultural deficient echo, and the need to undertake another communal actions was identified that they provoke the change and modify the picture of communal health. (shrink)

Se realizó una intervención comunitaria en el asentamiento rural "El León" de Camagüey basada en los resultados de un estudio anterior. Su objetivo fue implementar un sistema de acciones socio-sanitarias colectadas en un manual que organizó contenidos de antropología socio cultural, psicología y sociología de la salud, fue conducida por profesionales de enfermería cuyo encargo social les asigna una mayor permanencia e intercambio con los pobladores. Se potenció el trabajo comunitario a partir de febrero de 2010. La investigación constituyó un (...) diseño mixto, con un estudio cuasi experimental sin grupo control combinado con métodos cualitativos. La evaluación final efectuada en el periodo 2013-2015 exhibió modificaciones positivas en indicadores del Análisis de la Situación de Salud y el entorno comunitario. Se demostró la importancia de la aplicación de las acciones comunitarias por el personal de enfermería como agente de cambio de desarrollo local y protagonista de sostenibilidad. A community intervention was carried out at the rural settlement "El León". Its objective was to implement a system of actions led by nursing professionals whose social role assigns them longer permanence and interchange with the inhabitants of the community. Community work was fostered from February 2010 with social and sanitary actions based on socio-cultural anthropology, psychology and health sociology knowledge. The investigation had a mixed design, being a quasi-experimental study without control group combined with qualitative methods. The final evaluation, which took place from 2013-2015, showed positive modifications in Health Analysis indicators and community environment. The importance of the application of community actions by nursing personnel as agents of change for local development and sustainability leaders was demonstrated. (shrink)